BP501T. MEDICINAL CHEMISTRY – II (Theory) 45 Hours Scope: This subject is designed to impart fundamental knowledge on the structure, chemistry and therapeutic value of drugs. The subject emphasizes on structure activity relationships of drugs, importance of physicochemical properties and metabolism of drugs. The syllabus also emphasizes on chemical synthesis of important drugs under each class. Objectives: Upon completion of the course the student shall be able to 1. Understand the chemistry of drugs with respect to their pharmacological activity 2. Understand the drug metabolic pathways, adverse effect and therapeutic value of drugs 3. Know the Structural Activity Relationship of different class of drugs 4. Study the chemical synthesis of selected drugs Course Content:
Study of the development of the following classes of drugs, Classification, mechanism of action, uses of drugs mentioned in the course, Structure activity relationship of selective class of drugs as specified in the course and synthesis of drugs superscripted (*)
UNIT- I 10 Hours
Antihistaminic agents: Histamine, receptors and their distribution in the humanbody A. H1–antagonists: Diphenhydramine hydrochloride*, Dimenhydrinate, Doxylamines cuccinate, Clemastine fumarate, Diphenylphyraline hydrochloride, Tripelenamine hydrochloride, Chlorcyclizine hydrochloride, Meclizine hydrochloride, Buclizine hydrochloride, Chlorpheniramine maleate, Triprolidine hydrochloride*, Phenidamine tartarate, Promethazine hydrochloride*, Trimeprazine tartrate, Cyproheptadine hydrochloride, Azatidine maleate, Astemizole, Loratadine, Cetirizine, Levocetrazine Cromolyn sodium B. C. H2-antagonists: Cimetidine*, Famotidine, Ranitidin. D. E. Gastric Proton pump inhibitors: Omeprazole, Lansoprazole, Rabeprazole, Pantoprazole
Anti-neoplastic agents: A. Alkylating agents: Meclorethamine*, Cyclophosphamide, Melphalan
Chlorambucil, Busulfan, Thiotepa B. Antimetabolites: Mercaptopurine*, Thioguanine, Fluorouracil, Floxuridine, Cytarabine, Methotrexate*, Azathioprine C. Antibiotics: Dactinomycin, Daunorubicin, Doxorubicin, Bleomycin D. Plant products: Etoposide, Vinblastin sulphate, Vincristin sulphate E. Miscellaneous: Cisplatin, Mitotane.
UNIT – II 10 Hours
Anti-anginal: Vasodilators: Amyl nitrite, Nitroglycerin*, Pentaerythritol tetranitrate, Isosorbide dinitrite*, Dipyridamole. Calcium channel blockers: Verapamil, Bepridil hydrochloride, Diltiazem hydrochloride, Nifedipine, Amlodipine, Felodipine, Nicardipine, Nimodipine.
Diuretics: Carbonic anhydrase inhibitors: Acetazolamide*, Methazolamide, Dichlorphenamide. Thiazides: Chlorthiazide*, Hydrochlorothiazide, Hydroflumethiazide, Cyclothiazide, Loop diuretics: Furosemide*, Bumetanide, Ethacrynic acid. Potassium sparing Diuretics: Spironolactone, Triamterene, Amiloride. Osmotic Diuretics: Mannitol
Anti-hypertensive Agents: Timolol, Captopril, Lisinopril, Enalapril, Benazepril hydrochloride, Quinapril hydrochloride, Methyldopate hydrochloride,* Clonidine hydrochloride, Guanethidine monosulphate, Guanabenz acetate, Sodium nitroprusside, Diazoxide, Minoxidil, Reserpine, Hydralazine hydrochloride.
UNIT- III 10 Hours
Anti-arrhythmic Drugs: Quinidine sulphate, Procainamide hydrochloride, Disopyramide phosphate*, Phenytoin sodium, Lidocaine hydrochloride, Tocainide hydrochloride, Mexiletine hydrochloride, Lorcainide hydrochloride, Amiodarone, Sotalol.
Anti-hyperlipidemic agents: Clofibrate, Lovastatin, Cholesteramine and Cholestipol
Coagulant & Anticoagulants: Menadione, Acetomenadione, Warfarin*, Anisindione, clopidogrel
Drugs used in Congestive Heart Failure: Digoxin, Digitoxin, Nesiritide
UNIT- IV 08 Hours
Drugs acting on Endocrine system Nomenclature, Stereochemistry and metabolism of steroids
A. Sex hormones: Testosterone, Nandralone, Progestrones, Oestriol, Oestradiol, Oestrione, Diethyl stilbestrol. B. Drugs for erectile dysfunction: Sildenafil, Tadalafil. C. Oral contraceptives: Mifepristone, Norgestril, Levonorgestrol D. Corticosteroids: Cortisone, Hydrocortisone, Prednisolone, Betamethasone, Dexamethasone E. Thyroid and antithyroid drugs: L-Thyroxine, L-Thyronine, Propylthiouracil, Methimazole.
UNIT – V 07 Hours Antidiabetic agents: Insulin and its preparations Sulfonyl ureas: Tolbutamide*, Chlorpropamide, Glipizide, Glimepiride. Biguanides: Metformin. Thiazolidinediones: Pioglitazone, Rosiglitazone. Meglitinides: Repaglinide, Nateglinide. Glucosidase inhibitors: Acrabose, Voglibose.
Local Anesthetics: SAR of Local anesthetics Benzoic Acid derivatives; Cocaine, Hexylcaine, Meprylcaine, Cyclomethycaine, Piperocaine. Amino Benzoic acid derivatives: Benzocaine*, Butamben, Procaine*, Butacaine, Propoxycaine, Tetracaine, Benoxinate. Lidocaine/Anilide derivatives: Lignocaine, Mepivacaine, Prilocaine, Etidocaine. Miscellaneous: Phenacaine, Diperodon, Dibucaine.*
Recommended Books (Latest Editions) 1. Wilson and Giswold’s Organic medicinal and Pharmaceutical Chemistry. 2. Foye’s Principles of Medicinal Chemistry. 3. Burger’s Medicinal Chemistry, Vol I to IV. 4. Introduction to principles of drug design- Smith and Williams. 5. Remington’s Pharmaceutical Sciences. 6. Martindale’s extra pharmacopoeia. 7. Organic Chemistry by I.L. Finar, Vol. II.
BP 502 T. FORMULATIVEPHARMACY (Theory) 45 Hours Scope: Course enables the student to understand and appreciate the influence of pharmaceutical additives and various pharmaceutical dosage forms on the performance of the drug product.
Objectives: Upon completion of the course the student shall be able to 1. Know the various pharmaceutical dosage forms and their manufacturing techniques. 2. Know various considerations in development of pharmaceutical dosage forms 3. Formulate solid, liquid and semisolid dosage forms and evaluate them for their quality
Course content:
3 hours/ week UNIT-I 07 Hours Preformulation Studies: Introduction to preformulation, goals and objectives, study of physicochemical characteristics of drug substances. a. Physical properties: Physical form (crystal & amorphous), particle size, shape, flow properties, solubility profile (pKa, pH, partition coefficient), polymorphism b. Chemical Properties: Hydrolysis, oxidation, reduction, racemisation, polymerization BCS classification of drugs Application of preformulation considerations in the development of solid, liquid oral and parenteral dosage forms and its impact on stability of dosage forms.
UNIT-II 10 Hours Tablets: a. Introduction, ideal characteristics of tablets, classification of tablets. Excipients, Formulation of tablets, granulation methods, compression and processing problems. Equipments and tablet tooling. b. Tablet coating: Types of coating, coating materials, formulation of coating composition, methods of coating, equipment employed and defects in coating. c. Quality control tests: In process and finished product tests
Liquid orals: Formulation and manufacturing consideration of solutions, suspensions and emulsions; Filling and packaging; evaluation of liquid orals official in pharmacopoeia
UNIT-III 08 Hours Capsules: a. Hard gelatin capsules: Introduction, Extraction of gelatin and production of hard gelatin capsule shells. size of capsules, Filling, finishing and special techniques of formulation of hard gelatin capsules. In process and final product quality control tests for capsules. b. Soft gelatin capsules: Nature of shell and capsule content, size of capsules,importance of base adsorption and minimum/gram factors, production, in process and final product quality control tests. Packing, storage and stability testing of soft gelatin capsules Pellets: Introduction, formulation requirements, pelletization process, equipments for manufacture of pellets
UNIT-IV 10 Hours Parenteral Products: a. Definition, types, advantages and limitations. Preformulation factors and essential requirements, vehicles, additives, importance of isotonicity b. Production procedure, production facilities and controls. c. Formulation of injections, sterile powders, emulsions, suspensions, large volume parenterals and lyophilized products, Sterilization. d. Containers and closures selection, filling and sealing of ampoules, vials and infusion fluids. Quality control tests. Ophthalmic Preparations: Introduction, formulation considerations; formulation of eye drops, eye ointments and eye lotions; methods of preparation; labeling, containers; evaluation of ophthalmic preparations UNIT-V 10 Hours Cosmetics: Formulation and preparation of the following cosmetic preparations: lipsticks, shampoos, cold cream and vanishing cream, tooth pastes, hair dyes and sunscreens. Pharmaceutical Aerosols: Definition, propellants, containers, valves, types of aerosol systems; formulation and manufacture of aerosols; Evaluation of aerosols; Quality control and stability studies. Packaging Materials Science: Materials used for packaging of pharmaceutical products, factors influencing choice of containers, legal and official requirements for containers, stability aspects of packaging materials, quality control tests.
Ophthalmic Preparations: Introduction, formulation considerations; formulation of eye drops, eye ointments and eye lotions; methods of preparation; labeling, containers; evaluation of ophthalmic preparations UNIT-V 10 Hours Cosmetics: Formulation and preparation of the following cosmetic preparations: lipsticks, shampoos, cold cream and vanishing cream, tooth pastes, hair dyes and sunscreens. Pharmaceutical Aerosols: Definition, propellants, containers, valves, types of aerosol systems; formulation and manufacture of aerosols; Evaluation of aerosols; Quality control and stability studies. Packaging Materials Science: Materials used for packaging of pharmaceutical products, factors influencing choice of containers, legal and official requirements for containers, stability aspects of packaging materials, quality control tests.
114
BP 506 P. FORMULATIVEPHARMACY (Practical) 4 Hours/week 1. Preformulation study for prepared granules 2. Preparation and evaluation of Paracetamol tablets 3. Preparation and evaluation of Aspirin tablets 4. Coating of tablets 5. Preparation and evaluation of Tetracycline capsules 6. Preparation of Calcium Gluconate injection 7. Preparation of Ascorbic Acid injection 8. Preparation of Paracetamol Syrup 9. Preparation of Eye drops 10. Preparation of Pellets by extrusion spheronization technique 11. Preparation of Creams (cold / vanishing cream) 12. Evaluation of Glass containers
Recommended Books: (Latest Editions) 1. Pharmaceutical dosage forms - Tablets, volume 1 -3 by H.A. Liberman, Leon Lachman &J.B.Schwartz 2. Pharmaceutical dosage form - Parenteral medication vol- 1&2 by Liberman & Lachman 3. Pharmaceutical dosage form disperse system VOL-1 by Liberman & Lachman 4. Modern Pharmaceutics by Gilbert S. Banker & C.T. Rhodes, 3rd Edition 5. Remington: The Science and Practice of Pharmacy, 20th edition Pharmaceutical Science (RPS) 6. Theory and Practice of Industrial Pharmacy by Liberman & Lachman 7. Pharmaceutics- The science of dosage form design by M.E.Aulton, Churchill livingstone, Latest edition 8. Introduction to Pharmaceutical Dosage Forms by H. C.Ansel, Lea &Febiger, Philadelphia, 5thedition, 2005 9. Drug stability - Principles and practice by Cartensen & C.J. Rhodes, 3rd Edition, Marcel Dekker Series, Vol 107.
115
BP503.T. PHARMACOLOGY-II (Theory) 45 Hours
Scope: This subject is intended to impart the fundamental knowledge on various aspects (classification, mechanism of action, therapeutic effects, clinical uses, side effects and contraindications) of drugs acting on different systems of body and in addition,emphasis on the basic concepts of bioassay.
Objectives: Upon completion of this course the student should be able to 1. Understand the mechanism of drug action and its relevance in the treatment of different diseases 2. Demonstrate isolation of different organs/tissues from the laboratory animals by simulated experiments 3. Demonstrate the various receptor actions using isolated tissue preparation 4. Appreciate correlation of pharmacology with related medical sciences Course Content: UNIT-I 10hours 1. Pharmacology of drugs acting on cardio vascular system a. Introduction to hemodynamic and electrophysiology of heart. b. Drugs used in congestive heart failure c. Anti-hypertensive drugs. d. Anti-anginal drugs. e. Anti-arrhythmic drugs. f. Anti-hyperlipidemic drugs.
UNIT-II 10hours 1. Pharmacology of drugs acting on cardio vascular system a. Drug used in the therapy of shock. b. Hematinics, coagulants and anticoagulants. c. Fibrinolytics and anti-platelet drugs d. Plasma volume expanders 2. Pharmacology of drugs acting on urinary system a. Diuretics b. Anti-diuretics.
UNIT-III 10hours 3. Autocoids and related drugs a. Introduction to autacoids and classification b. Histamine, 5-HT and their antagonists. c. Prostaglandins, Thromboxanes and Leukotrienes. d. Angiotensin, Bradykinin and Substance P. e. Non-steroidal anti-inflammatory agents f. Anti-gout drugs g. Antirheumatic drugs
116
UNIT-IV 08hours 5. Pharmacology of drugs acting on endocrine system a. Basic concepts in endocrine pharmacology. b. Anterior Pituitary hormones- analogues and their inhibitors. c. Thyroid hormones- analogues and their inhibitors. d. Hormones regulating plasma calcium level- Parathormone, Calcitonin and Vitamin-D. d. Insulin, Oral Hypoglycemic agents and glucagon. e. ACTH and corticosteroids.
UNIT-V 07hours 5. Pharmacology of drugs acting on endocrine system a. Androgens and Anabolic steroids. b. Estrogens, progesterone and oral contraceptives. c. Drugs acting on the uterus. 6. Bioassay a. Principles and applications of bioassay. b.Types of bioassay c. Bioassay of insulin, oxytocin, vasopressin, ACTH,d-tubocurarine,digitalis, histamine and 5-HT
117
BP 507 P. PHARMACOLOGY-II (Practical) 4Hrs/Week
1. Introduction to in-vitro pharmacology and physiological salt solutions. 2. Effect of drugs on isolated frog heart. 3. Effect of drugs on blood pressure and heart rate of dog. 4. Study of diuretic activity of drugs using rats/mice. 5. DRC of acetylcholine using frog rectus abdominis muscle. 6. Effect of physostigmine and atropine on DRC of acetylcholine using frog rectus abdominis muscle and rat ileum respectively. 7. Bioassay of histamine using guinea pig ileum by matching method. 8. Bioassay of oxytocin using rat uterine horn by interpolation method. 9. Bioassay of serotonin using rat fundus strip by three point bioassay. 10. Bioassay of acetylcholine using rat ileum/colon by four point bioassay. 11. Determination of PA2 value of prazosin using rat anococcygeus muscle (by Schilds plot method). 12. Determination of PD2 value using guinea pig ileum. 13. Effect of spasmogens and spasmolytics using rabbit jejunum. 14. Anti-inflammatory activity of drugs using carrageenan induced paw-edema model. 15. Analgesic activity of drug using central and peripheral methods
Note: All laboratory techniques and animal experiments are demonstrated by simulated experiments by softwares and videos
Recommended Books (Latest Editions) 1. Rang H. P., Dale M. M., Ritter J. M., Flower R. J., Rang and Dale’s Pharmacology, Churchil Livingstone Elsevier 2. Katzung B. G., Masters S. B., Trevor A. J., Basic and clinical pharmacology, Tata Mc Graw-Hill. 3. Goodman and Gilman’s, The Pharmacological Basis of Therapeutics 4. Marry Anne K. K., Lloyd Yee Y., Brian K. A., Robbin L.C., Joseph G. B., Wayne A. K., Bradley R.W., Applied Therapeutics, The Clinical use of Drugs, The Point Lippincott Williams & Wilkins. 5. Mycek M.J, Gelnet S.B and Perper M.M. Lippincott’s Illustrated Reviews- Pharmacology. 6. K.D.Tripathi. Essentials of Medical Pharmacology, , JAYPEE Brothers Medical Publishers (P) Ltd, New Delhi. 7. Sharma H. L., Sharma K. K., Principles of Pharmacology, Paras medical publisher 8. Modern Pharmacology with clinical Applications, by Charles R.Craig& Robert. 9. Ghosh MN. Fundamentals of Experimental Pharmacology. Hilton & Company, Kolkata. 10. Kulkarni SK. Handbook of experimental pharmacology. Vallabh Prakashan.
118
BP504 T. PHARMACOGNOSY AND PHYTOCHEMISTRY II (Theory) 45Hours Scope: The main purpose of subject is to impart the students the knowledge of how the secondary metabolites are produced in the crude drugs, how to isolate and identify and produce them industrially. Also this subject involves the study of producing the plants and phytochemicals through plant tissue culture, drug interactions and basic principles of traditional system of medicine Objectives: Upon completion of the course, the student shall be able 1. to know the modern extraction techniques, characterization and identification of the herbal drugs and phytoconstituents 2. to understand the preparation and development of herbal formulation. 3. to understand the herbal drug interactions 4. to carryout isolation and identification of phytoconstituents
Course Content: UNIT-I 7 Hours Metabolic pathways in higher plants and their determination a) Brief study of basic metabolic pathways and formation of different secondary metabolites through these pathways- Shikimic acid pathway, Acetate pathways and Amino acid pathway. b) Study of utilization of radioactive isotopes in the investigation of Biogenetic studies.
UNIT-II 20 Hours General introduction, composition, chemistry & chemical classes, general methods of extraction & analysis, biosources, therapeutic uses and commercial applications of following secondary metabolites:
Alkaloids: Vinca, Rauwolfia, Belladonna, Opium, Phenylpropanoids and Flavonoids: Lignans, Tea, Ruta Steroids, Cardiac Glycosides & Triterpenoids: Liquorice, Dioscorea, Digitalis Volatile oils: Mentha, Clove, Cinnamon, Fennel, Coriander, Tannins: Catechu, Pterocarpus Resins: Benzoin, Guggul, Ginger, Asafoetida, Myrrh, Colophony Glycosides: Senna, Aloes, Bitter Almond Iridoids, Other terpenoids & Naphthaquinones: Gentian, Artemisia, taxus, carotenoids
UNIT-III 10 Hours Industrial production, estimation and utilization of the following phytoconstituents: Forskolin, Sennoside, Artemisinin, Diosgenin, Digoxin, Atropine, Podophyllotoxin, Caffeine, Taxol, Vincristine and Vinblastine
UNIT IV 8 Hours Basics of Phytochemistry Modern methods of extraction, application of latest techniques like Spectroscopy, chromatography and electrophoresis in the isolation, purification and identification of crude drugs.
120
BP 508 P. PHARMACOGNOSY AND PHYTOCHEMISTRY II (Practical) 4 Hours/Week
1. Morphology, histology and powder characteristics & extraction & detection of: Cinchona, Cinnamon, Senna, Clove, Ephedra, Fennel and Coriander 2. Exercise involving isolation & detection of active principles a. Caffeine - from tea dust. b. Diosgenin from Dioscorea c. Atropine from Belladonna d. Sennosides from Senna 3. Separation of sugars by Paper chromatography 4. TLC of herbal extract 5. Distillation of volatile oils and detection of phytoconstitutents by TLC 6. Analysis of crude drugs by chemical tests: (i) Asafoetida (ii) Benzoin (iii) Colophony (iv) Aloes (v) Myrrh
Recommended Books: (Latest Editions) 1. W.C.Evans, Trease and Evans Pharmacognosy, 16th edition, W.B. Sounders & Co., London, 2009. 2. Mohammad Ali. Pharmacognosy and Phytochemistry, CBS Publishers & Distribution, New Delhi. 3. Text book of Pharmacognosy by C.K. Kokate, Purohit, Gokhlae (2007), 37th Edition, Nirali Prakashan, New Delhi. 4. Herbal drug industry by R.D. Choudhary (1996), Ist Edn, Eastern Publisher, New Delhi. 5. Essentials of Pharmacognosy, Dr.SH.Ansari, IInd edition, Birla publications, New Delhi, 2007 6. Herbal Cosmetics by H.Pande, Asia Pacific Business press, Inc, New Delhi. 7. A.N. Kalia, Textbook of Industrial Pharmacognosy, CBS Publishers, New Delhi, 2005. 8. R Endress, Plant cell Biotechnology, Springer-Verlag, Berlin, 1994. 9. Pharmacognosy & Pharmacobiotechnology. James Bobbers, Marilyn KS, VE Tylor. 10. The formulation and preparation of cosmetic, fragrances and flavours. 11. Remington’s Pharmaceutical sciences. 12. Text Book of Biotechnology by Vyas and Dixit. 13. Text Book of Biotechnology by R.C. Dubey.
121
BP 505 T. PHARMACEUTICAL JURISPRUDENCE (Theory)
45 Hours
Scope: This course is designed to impart basic knowledge on several important legislations related to the profession of pharmacy in India. Objectives: Upon completion of the course, the student shall be able to understand: 1. The Pharmaceutical legislations and their implications in the development and marketing 2. Various Indian pharmaceutical Acts and Laws 3. The regulatory authorities and agencies governing the manufacture and sale of pharmaceuticals 4. The code of ethics during the pharmaceutical practice Course Content:
UNIT-I 10 Hours
Drugs and Cosmetics Act, 1940 and its rules 1945: Objectives, Definitions, Legal definitions of schedules to the act and rules Import of drugs – Classes of drugs and cosmetics prohibited from import, Import under license or permit. Offences and penalties. Manufacture of drugs – Prohibition of manufacture and sale of certain drugs, Conditions for grant of license and conditions of license for manufacture of drugs, Manufacture of drugs for test, examination and analysis, manufacture of new drug, loan license and repacking license.
UNIT-II 10 Hours
Drugs and Cosmetics Act, 1940 and its rules 1945. Detailed study of Schedule G, H, M, N, P,T,U, V, X, Y, Part XII B, Sch F & DMR (OA) Sale of Drugs – Wholesale, Retail sale and Restricted license. Offences and penalties Labeling & Packing of drugs- General labeling requirements and specimen labels for drugs and cosmetics, List of permitted colors. Offences and penalties. Administration of the act and rules – Drugs Technical Advisory Board, Central drugs Laboratory, Drugs Consultative Committee, Government drug analysts, Licensing authorities, controlling authorities, Drugs Inspectors
UNIT-III 10 Hours
Pharmacy Act –1948: Objectives, Definitions, Pharmacy Council of India; its constitution and functions, Education Regulations, State and Joint state pharmacy councils; its constitution and functions, Registration of Pharmacists, Offences and
123
Penalties Medicinal and Toilet Preparation Act –1955: Objectives, Definitions, Licensing, Manufacture In bond and Outside bond, Export of alcoholic preparations, Manufacture of Ayurvedic, Homeopathic, Patent & Proprietary Preparations. Offences and Penalties. Narcotic Drugs and Psychotropic substances Act-1985 and Rules: Objectives, Definitions, Authorities and Officers, Constitution and Functions of narcotic & Psychotropic Consultative Committee, National Fund for Controlling the Drug Abuse, Prohibition, Control and Regulation, opium poppy cultivation and production of poppy straw, manufacture, sale and export of opium, Offences and Penalties
UNIT-IV 08 Hours
Study of Salient Features of Drugs and magic remedies Act and its rules: Objectives, Definitions, Prohibition of certain advertisements, Classes of Exempted advertisements, Offences and Penalties Prevention of Cruelty to animals Act-1960: Objectives, Definitions, Institutional Animal Ethics Committee, Breeding and Stocking of Animals, Performance of Experiments, Transfer and acquisition of animals for experiment, Records, Power to suspend or revoke registration, Offences and Penalties National Pharmaceutical Pricing Authority: Drugs Price Control Order (DPCO)2013. Objectives, Definitions, Sale prices of bulk drugs, Retail price of formulations, Retail price and ceiling price of scheduled formulations, National List of Essential Medicines (NLEM)
UNIT-V 07 Hours
Pharmaceutical Legislations – A brief review, Introduction, Study of drugs enquiry committee, Health survey and development committee, Hathi committee and Mudaliar committee Code of Pharmaceutical ethics D efinition, Pharmacist in relation to his job, trade, medical profession and his profession, Pharmacist’s oath Medical Termination of pregnancy act Right to information Act Introduction to Intellectual Property Rights (IPR)
Recommended books: (Latest Edition) 1. Forensic Pharmacy by B. Suresh
124
2. Text book of Forensic Pharmacy by B.M. Mithal 3. Hand book of drug law-by M.L. Mehra 4. A text book of Forensic Pharmacy by N.K. Jain 5. Drugs and Cosmetics Act/Rules by Govt. of India publications. 6. Medicinal and Toilet preparations act 1955 by Govt. of India publications. 7. Narcotic drugs and psychotropic substances act by Govt. of India publications 8. Drugs and Magic Remedies act by Govt. of India publication 9.Bare Acts of the said laws published by Government. Reference books (Theory)
Download
Post a Comment
0 Comments